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CAC scans, and CAC phrpose are now increasingly popular, and the results are worrying lots of people who wonder what ldl purpose mean, and exactly how worried they should be. What is coronary artery calcification Coronary artery calcification CAC is the deposition of calcium in artery walls. At the risk of oversimplification, it is generally accepted that atherosclerotic plaques go through four stages Small Vulnerable Calcified Forget small and bigger. The important ones are vulnerable and calcified.
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pudpose What is a vulnerable plaque? It is a plaque that reaches a certain size undefined containing an almost liquid core, with a thin cap. If this thin cap ruptures, it exposes the liquid core to the bloodstream triggering a major blood clot than can fully ldl purpose a coronary artery and cause a myocardial infarction.
This is generally described ldl purpose plaque rupture. If it happens in an artery link the neck, a carotid artery, the clot will normally not be big enough to block the artery. But it can break off and head up here the brain, causing a stroke. Over time, assuming the vulnerable plaques do not rupture and kill you, some of them ldl purpose of them?
At which point they are less likely to rupture and may be considered relatively benign. Calcification of areas of damage in the ldl purpose is not restricted to atherosclerotic plaques. Almost any damaged area in the body, that is not perfectly repaired, is likely to calcify to some extent or another. Scars tend to be white, and the white is calcium. At the extreme end of calcification is a condition called myositis ossificans, whereby almost any damage ends up becoming bone. With damaged muscle turning into bone. This does not end well. Anyway, assuming you have plaques developing and growing in your arteries, they will in time calcify.
Or at least some of them will. Are some people genetically more likely to get calcification than others? Almost certainly. Some things are known to increase the rate of calcification. Statins, for example. Here from the Cleveland clinic: Patients with coronary artery disease CAD who are treated with statins experience an increase in coronary calcification, an effect lcl ldl purpose independent of plaque progression or regression.
Paradoxically, high-intensity statin therapy is associated with the largest increases in coronary calcification despite promoting atheroma regression 1 Ldl purpose statins the plaques get smaller and the calcium load gets bigger. Another drug that whacks up the rate of calcification is warfarin often called coumadin in the US. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature.
This increase in vascular calcification is due to inhibition of ldl purpose enzyme matrix ldl purpose Gla protein MGP. MGP is a vitamin K-dependent protein that ordinarily prevents systemic calcification by scavenging calcium phosphate in the tissues.
Accelerated coronary artery calcification, exercise-induced cardiac biomarker release, myocardial fibrosis, atrial fibrillation, and even higher risk of sudden cardiac death have been reported in athletes. Statins increase calcification Warfarin increases calcification Intense exercise increases calcification Yet, all three reduce the risk of dying of cardiovascular disease.]