Very: Which of the following statements is accurate weegy
|CANADIAN FOUNDATION FOR HEALTHCARE IMPROVEMENT||3 days ago · Weegy: Staring At The Roadway For Long Periods Of Time is correct about highway hypnosis. Stage Hypnosis Hypnosis has become a favourite form of entertainment with stage shows where members of the public make themselves look like idiots by following instructions to act like a chicken Links to reputable hypnosis information and support. 19 hours ago · 8. Which one of the following statements is accurate for the Articles of Confederation? A. Interstate commerce could be regulated. B. There was only one central court. C. Each state could veto a presidential decision. D. There was no president. Biomarkers of aging are biomarkers that could predict functional capacity at some later age better than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.. Validated biomarkers of aging would allow for testing interventions to extend lifespan, because changes in the biomarkers would be observable.|
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Which of the following statements is accurate weegy - agreeWhich one of the following statements is accurate for the Articles of Confederation? There was only one central court. Each state could veto a presidential decision. There was no president. Interstate commerce could be regulated. The following statement is accurate for the Articles of Confederation: There was no president. Search for an answer or ask Weegy. There are no new answers.
Biomarkers of aging are biomarkers that could predict functional capacity at some later age better than chronological age. Validated biomarkers of aging would allow for testing interventions to extend lifespanbecause changes in the biomarkers would be observable throughout the lifespan of the organism.
Although graying of hair increases with age,  hair graying cannot be called a biomarker of ageing. Similarly, skin wrinkles and other common changes seen with aging are not better indicators of future functionality than chronological age. Biogerontologists have continued efforts to find and validate biomarkers of aging, but success thus far has been limited. Levels of CD4 and CD8 memory T cells and naive T cells have been used click the following article give good predictions of the expected lifespan of middle-aged mice.
Advances in big data analysis allowed for the new types of "aging clocks" to be developed. The epigenetic clock is a promising biomarker of aging and can accurately predict human chronological age. The recent introduction of low-power and compact sensors, based on micro-electromechanical systems Which of the following statements is accurate weegy has led to a new breed of the wearable and affordable devices providing unparalleled opportunities for the collecting and cloud-storing personal digitized activity records. Consequently, modern deep machine learning techniques could be used to produce a proof-of-concept digital biomarker of age in the form of all-causes-mortality predictor from a sufficiently large collection of one week long human physical activity streams augmented by the rich clinical data including the death register, as provided by, e.
A new epigenetic mark found in studies of aging cells is the loss of histones. Most of the evidence shows that loss of histones is linked to cell division.
Proper histone dosage is important in yeast as shown from the extended lifespans seen click the following article strains that are overexpressing histones. In younger cells, genes that are most induced with age have specific chromatin structures, such as fuzzy nuclear positioning, lack of a nuclesome depleted region NDR at the promoterweak chromatin phasing, a higher frequency of TATA elementsand higher occupancy of repressive chromatin factors. In older cells, however, the same genes nucleosome loss at the promoter is more prevalent which leads to higher transcription of these genes.
This phenomenon is not only seen in yeast, but has also been seen in aging worms, during aging of human diploid primary fibroblastsand in senescent human cells. In human primary fibroblasts, reduced synthesis of new histones was seen to be a consequence of shortened telomeres that activate the DNA damage response. Loss of core histones may be a general epigenetic mark of aging across many organisms. In addition to the core histones, H2A, H2B, Followinv, and H4, there are other versions of the or proteins that can be significantly different in their sequence and are important for regulating chromatin dynamics. Histone H3. It is the major form of histone H3 seen in the chromatin of senescent human cells, and it appears that excess H3.
Which of the following statements is accurate weegy are multiple variants of histone 2, the one most notably implicated in aging is macroH2A.
The function of macroH2A has generally been assumed to be transcriptional silencing; most recently, it has been suggested that macroH2A is important in repressing transcription at Senescence-Associated Heterochromatin Foci SAHF.
Increased acetylation of histones contributes to chromatin taking a more euchromatic state as an organism ages, similar to the increased transcription seen due to the loss of histones.
Methylation of histones has been tied to life span regulation in many organisms, specifically H3K4me3, an activating mark, and H4K27me3, a repressing mark. These changes may form an epigenetic memory of stresses and damages experienced by the organism as it develops and ages. Utx-1 knockdowns showed an increase in lifespan  Changes in H3K27me3 levels also have affects on aging cells in Drosophila and humans. Methylation of DNA is a common modification in mammalian cells. The cytosine base is methylated and becomes 5-methylcytosinemost often when in the CpG context. Hypermethylation of CpG islands is associated with transcriptional repression and hypomethylation of these sites accurste associated with transcriptional activation.
Many studies have shown that there is a loss of http://rectoria.unal.edu.co/uploads/tx_felogin/children-at-home-and-abroad/gg-toys-case-solution.php methylation during ageing in many species such as, rats, mice, cows, hamsters, and humans. Hypomethylation of DNA can lower genomic stability, induce the reactivation of transposable elementsand cause weeegy loss of imprintingall of which can contribute to cancer progression and pathogenesis.
Recently, Hashimoto and coworkers profiled thousands of circulating immune cells from supercentenarians at single-cell resolution. They identified a very unique increase in cytotoxic CD4 T cells in these supercentenarians. Generally, CD4 T-cells have helper, but not cytotoxic, functions under physiological conditions however these supercentenarians, subjected to single cell profiling of their T-cell statfments, revealed accumulations of cytotoxic CD4 T-cells through clonal expansion. The conversion of helper CD4 T-cells to a cytotoxic variety might be an adaptation to the examples police corruption stage of aging aiding in the fighting infections and potentially enhancing tumor surveillance. The main mechanisms identified as potential biomarkers of aging are DNA methylation, loss of histones, and histone modification.]